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Atomfair 3-Chloro-5-((1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl)oxy)benzonitrile Doravirine metabolite M11 C13H6ClF3N2O2

Description 3-Chloro-5-((1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl)oxy)benzonitrile (CAS No. 1155846-86-8) is a high-purity synthetic organic compound with the molecular formula C13H6ClF3N2O2. This specialized chemical features a unique structural configuration, combining a chlorinated benzonitrile moiety with a trifluoromethyl-substituted dihydropyridinone ring via an ether linkage. As a key metabolite of Doravirine (M11), this compound is of significant interest in pharmaceutical research and development. We offer this product as a certified reference material with ??95% purity (HPLC), supplied in amber vials under inert atmosphere to ensure stability. Ideal for analytical standards, metabolic studies, and medicinal chemistry applications, this compound is rigorously characterized by1H NMR,13C NMR, LC-MS, and elemental…

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Description

Description

3-Chloro-5-((1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl)oxy)benzonitrile (CAS No. 1155846-86-8) is a high-purity synthetic organic compound with the molecular formula C13H6ClF3N2O2. This specialized chemical features a unique structural configuration, combining a chlorinated benzonitrile moiety with a trifluoromethyl-substituted dihydropyridinone ring via an ether linkage. As a key metabolite of Doravirine (M11), this compound is of significant interest in pharmaceutical research and development. We offer this product as a certified reference material with ??95% purity (HPLC), supplied in amber vials under inert atmosphere to ensure stability. Ideal for analytical standards, metabolic studies, and medicinal chemistry applications, this compound is rigorously characterized by 1H NMR, 13C NMR, LC-MS, and elemental analysis. Store at 2-8??C in a dry environment.

  • CAS No: 1155846-86-8
  • Molecular Formula: C13H6ClF3N2O2
  • Molecular Weight: 314.64
  • Exact Mass: 314.0069896
  • Monoisotopic Mass: 314.0069896
  • IUPAC Name: 3-chloro-5-[[2-oxo-4-(trifluoromethyl)-1H-pyridin-3-yl]oxy]benzonitrile
  • SMILES: C1=CNC(=O)C(=C1C(F)(F)F)OC2=CC(=CC(=C2)C#N)Cl
  • Synonyms: 3-chloro-5-((2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile, Doravirine metabolite M11, 25T4FX9UFY, 3-chloro-5-{[2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile, Benzonitrile, 3-chloro-5-[[1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-

Application

This compound serves as a crucial reference standard for the quantification and identification of Doravirine metabolites in pharmacokinetic studies. Researchers utilize it in LC-MS/MS method development for therapeutic drug monitoring in HIV treatment regimens. The structural features make it valuable for investigating metabolic pathways of non-nucleoside reverse transcriptase inhibitors. Additionally, it finds use in analytical method validation for regulatory compliance in pharmaceutical quality control.

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