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Atomfair 3-Pyridyl Trifluoromethanesulfonate C6H4F3NO3S

Description 3-Pyridyl Trifluoromethanesulfonate (CAS No. 107658-27-5) is a high-purity, organosulfur compound with the molecular formula C6H4F3NO3S . This reagent, also known as pyridin-3-yl trifluoromethanesulfonate, is a versatile triflate ester widely used in organic synthesis and pharmaceutical research. Its trifluoromethanesulfonate (triflate) group serves as an excellent leaving group, enabling efficient nucleophilic substitution reactions. The compound is characterized by its exceptional reactivity in cross-coupling reactions, such as Suzuki-Miyaura and Negishi couplings, making it invaluable for constructing complex heterocyclic scaffolds. Supplied as a crystalline solid or solution, it is rigorously tested for purity (typically ??97% by HPLC or GC analysis) and stored under…

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Description

Description

3-Pyridyl Trifluoromethanesulfonate (CAS No. 107658-27-5) is a high-purity, organosulfur compound with the molecular formula C6H4F3NO3S. This reagent, also known as pyridin-3-yl trifluoromethanesulfonate, is a versatile triflate ester widely used in organic synthesis and pharmaceutical research. Its trifluoromethanesulfonate (triflate) group serves as an excellent leaving group, enabling efficient nucleophilic substitution reactions. The compound is characterized by its exceptional reactivity in cross-coupling reactions, such as Suzuki-Miyaura and Negishi couplings, making it invaluable for constructing complex heterocyclic scaffolds. Supplied as a crystalline solid or solution, it is rigorously tested for purity (typically ??97% by HPLC or GC analysis) and stored under inert conditions to ensure stability. Ideal for researchers in medicinal chemistry, catalysis, and material science.

  • CAS No: 107658-27-5
  • Molecular Formula: C6H4F3NO3S
  • Molecular Weight: 227.16
  • Exact Mass: 226.98639865
  • Monoisotopic Mass: 226.98639865
  • IUPAC Name: pyridin-3-yl trifluoromethanesulfonate
  • SMILES: C1=CC(=CN=C1)OS(=O)(=O)C(F)(F)F
  • Synonyms: 3-Pyridyl Trifluoromethanesulfonate, 107658-27-5, DTXSID50452636, DTXCID40403455, 691-520-2

Application

3-Pyridyl Trifluoromethanesulfonate is a key intermediate in the synthesis of pharmaceuticals and agrochemicals, particularly for introducing pyridyl motifs via palladium-catalyzed cross-coupling reactions. It is employed in the preparation of kinase inhibitors and other bioactive molecules due to its ability to facilitate C-N and C-C bond formations. The compound’s triflate group also enhances electrophilicity in SN2 reactions, enabling efficient functionalization of pyridine derivatives.

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