Description

Description

Tert-butyl 4-hydroxypiperidine-1-carboxylate (CAS No. 103962-05-6) is a high-purity organic compound with the molecular formula C₁₀H₁₉NO₃. This Boc-protected piperidine derivative is widely utilized in pharmaceutical research, medicinal chemistry, and organic synthesis. The compound features a hydroxyl group at the 4-position of the piperidine ring, enhancing its reactivity for further functionalization. Its tert-butoxycarbonyl (Boc) protecting group ensures stability during synthetic transformations while allowing for easy deprotection under mild acidic conditions. Supplied as a white to off-white crystalline solid, it is rigorously tested for quality, including HPLC, NMR, and mass spectrometry verification. Ideal for use as a versatile intermediate in the synthesis of bioactive molecules, peptidomimetics, and heterocyclic compounds. Store in a cool, dry place under inert conditions to maintain optimal stability.

Application

Tert-butyl 4-hydroxypiperidine-1-carboxylate serves as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors and central nervous system (CNS) active compounds. Its hydroxyl group allows for further derivatization, enabling the construction of complex molecular architectures. The Boc-protected amine functionality is instrumental in peptide coupling reactions and solid-phase synthesis. Researchers also employ this compound in the preparation of chiral auxiliaries and catalysts for asymmetric synthesis. Its versatility makes it valuable in both academic and industrial R&D settings.

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