Description

3-Fluoro-N-methoxy-N-methylbenzamide (CAS No. 226260-01-1) is a high-purity fluorinated benzamide derivative with the molecular formula C₉H₁₀FNO₂. This compound is widely utilized in organic synthesis, pharmaceutical research, and material science due to its unique structural properties. The presence of both fluorine and methoxy-N-methylamide moieties enhances its reactivity, making it a valuable intermediate for constructing complex molecules. It is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring consistency for research applications. Proper storage under inert conditions at 2-8°C is recommended to maintain stability.

Properties

• CAS Number: 226260-01-1
• Complexity: 186
• IUPAC Name: 3-fluoro-N-methoxy-N-methyl-benzamide
• InChI: InChI=1S/C9H10FNO2/c1-11(13-2)9(12)7-4-3-5-8(10)6-7/h3-6H,1-2H3
• InChI Key: RQOXEMMAAVCMRU-UHFFFAOYSA-N
• Exact Mass: 183.06955672
• Molecular Formula: C9H10FNO2
• Molecular Weight: 183.18
• SMILES: CN(C(=O)C1=CC(=CC=C1)F)OC
• Topological: 29.5
• Monoisotopic Mass: 183.06955672
• Synonyms: 3-FLUORO-N-METHOXY-N-METHYLBENZAMIDE, 226260-01-1, MFCD02684305, SCHEMBL305837, DTXSID90611785, RQOXEMMAAVCMRU-UHFFFAOYSA-N, 3-fluoro-n-methoxy-n-methyl-benzamide, AKOS008952703, DS-6267, PB42126, Benzamide, 3-fluoro-N-methoxy-N-methyl-, SY108464, CS-0123012, P18083, Z54739369

Application

3-Fluoro-N-methoxy-N-methylbenzamide serves as a versatile building block in medicinal chemistry for the synthesis of fluorinated drug candidates. Its electron-withdrawing fluorine group facilitates selective cross-coupling reactions, while the Weinreb amide functionality enables controlled carbonyl transformations. Researchers employ this compound in the development of kinase inhibitors and CNS-targeting molecules. It is also used in material science to modify polymer properties via incorporation of fluorinated aromatic units.

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